MovDisordV3, Main, Exploration, bibRecord, 003A58

Serum from Sydenham's chorea patients modifies intracellular calcium levels in PC12 cells by a complement-independent mechanism

Identifieur interne : 003A58 ( Main/Exploration ); précédent : 003A57; suivant : 003A59

Serum from Sydenham's chorea patients modifies intracellular calcium levels in PC12 cells by a complement-independent mechanism

Auteurs : Antonio L. Jr Teixeira [Brésil] ; Melissa M. Guimaraes [Brésil] ; Marco Aurélio Romano-Silva [Brésil] ; Francisco Cardoso [Brésil]

Source :

Movement disorders [ 0885-3185 ] ; 2005.

RBID : Pascal:05-0387178

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Chorée Sydenham, Streptococcie, Homme, Intracellulaire, Calcium, Complément, Noyau gris central, Streptococcus.
Wicri :
- topic : Homme, Calcium.

English descriptors

KwdEn :
- Basal ganglion, Calcium, Complement, Human, Intracellular, Nervous system diseases, Streptococcal infection, Streptococcus, Sydenham chorea.

Abstract

The proposed pathogenesis of Sydenham's chorea (SC) is an autoantibody-mediated basal ganglia dysfunction. Our study has shown that incubation of PC12 cells with complement-inactivated serum from SC patients was associated with a significant increase in Ca²⁺ levels evoked by KCl stimulus (mean ± SEM, 341.0 ± 8.7% of fluorescence intensity, arbitrary units) when compared with incubation with control serum (313.8 ± 8.7% of fluorescence intensity, arbitrary units; P = 0.01). The increase in Ca²⁺ levels determined by SC patients sera correlated directly with the enzyme-linked immunosorbent assay optical density values for anti-basal ganglia antibodies. Our study supports the hypothesis that antibodies against basal ganglia in SC may cause their dysfunction.

Affiliations:

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Le document en format XML

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<author><name sortKey="Guimaraes, Melissa M" sort="Guimaraes, Melissa M" uniqKey="Guimaraes M" first="Melissa M." last="Guimaraes">Melissa M. Guimaraes</name>
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<author><name sortKey="Romano Silva, Marco Aurelio" sort="Romano Silva, Marco Aurelio" uniqKey="Romano Silva M" first="Marco Aurélio" last="Romano-Silva">Marco Aurélio Romano-Silva</name>
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<region type="state">Minas Gerais</region>
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<author><name sortKey="Cardoso, Francisco" sort="Cardoso, Francisco" uniqKey="Cardoso F" first="Francisco" last="Cardoso">Francisco Cardoso</name>
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<s3>BRA</s3>
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<sZ>4 aut.</sZ>
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<country>Brésil</country>
<placeName><settlement type="city">Belo Horizonte</settlement>
<region type="state">Minas Gerais</region>
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<orgName type="university">Université fédérale du Minas Gerais</orgName>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Basal ganglion</term>
<term>Calcium</term>
<term>Complement</term>
<term>Human</term>
<term>Intracellular</term>
<term>Nervous system diseases</term>
<term>Streptococcal infection</term>
<term>Streptococcus</term>
<term>Sydenham chorea</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term>
<term>Chorée Sydenham</term>
<term>Streptococcie</term>
<term>Homme</term>
<term>Intracellulaire</term>
<term>Calcium</term>
<term>Complément</term>
<term>Noyau gris central</term>
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<front><div type="abstract" xml:lang="en">The proposed pathogenesis of Sydenham's chorea (SC) is an autoantibody-mediated basal ganglia dysfunction. Our study has shown that incubation of PC12 cells with complement-inactivated serum from SC patients was associated with a significant increase in Ca<sup>2+</sup>
 levels evoked by KCl stimulus (mean ± SEM, 341.0 ± 8.7% of fluorescence intensity, arbitrary units) when compared with incubation with control serum (313.8 ± 8.7% of fluorescence intensity, arbitrary units; P = 0.01). The increase in Ca<sup>2+</sup>
 levels determined by SC patients sera correlated directly with the enzyme-linked immunosorbent assay optical density values for anti-basal ganglia antibodies. Our study supports the hypothesis that antibodies against basal ganglia in SC may cause their dysfunction.</div>
</front>
</TEI>
<affiliations><list><country><li>Brésil</li>
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<tree><country name="Brésil"><region name="Minas Gerais"><name sortKey="Teixeira, Antonio L Jr" sort="Teixeira, Antonio L Jr" uniqKey="Teixeira A" first="Antonio L. Jr" last="Teixeira">Antonio L. Jr Teixeira</name>
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<name sortKey="Cardoso, Francisco" sort="Cardoso, Francisco" uniqKey="Cardoso F" first="Francisco" last="Cardoso">Francisco Cardoso</name>
<name sortKey="Guimaraes, Melissa M" sort="Guimaraes, Melissa M" uniqKey="Guimaraes M" first="Melissa M." last="Guimaraes">Melissa M. Guimaraes</name>
<name sortKey="Romano Silva, Marco Aurelio" sort="Romano Silva, Marco Aurelio" uniqKey="Romano Silva M" first="Marco Aurélio" last="Romano-Silva">Marco Aurélio Romano-Silva</name>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Serum from Sydenham's chorea patients modifies intracellular calcium levels in PC12 cells by a complement-independent mechanism

Serum from Sydenham's chorea patients modifies intracellular calcium levels in PC12 cells by a complement-independent mechanism

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri